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HERC5 Antibody - middle region : HRP (ARP43213_P050-HRP)

Product Specifications

Gene Name

HECT and RLD domain containing E3 ubiquitin protein ligase 5

Gene Aliases

CEB1, CEBP1

Gene ID

51191

Swiss Prot

Q69G20

Accession Number

NP_057407

Host

Rabbit

Reactivity

Human, Rat, Cow, Horse, Pig, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human HERC5

Target

HERC5 is a member of the HERC family of ubiquitin ligases.It contains a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulates expression of HERC5 protein in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets.This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The gene lies in a cluster of HERC family genes on chromosome 4.

Partner Proteins

UBC; SMAD4; UBE2D1; gag; ISG15; TXNRD1; IRF3; HSPA8; CTNNB1; HERC5; SIRT7; STK38; PITX2; ERCC2; CCND1; CCNE1; CCNB1; CCNA2; NME2; CDKN1A

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

IHC, WB

Purification

Affinity Purified

Sample Type

HERC5 is supported by BioGPS gene expression data to be expressed in HEK293

Concentration

0.5 mg/ml

Homology

Cow: 79%; Horse: 79%; Human: 100%; Pig: 79%; Rabbit: 86%; Rat: 79%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

117kDa

References & Citations

Salon, C., (2007) Oncogene 26 (48), 6927-6936

Shipping Conditions

Wet Ice

Protein Length

1024

NCBI Gene Symbol

HERC5

NCBI GB Accession Number

HERC5

Host or Source

Rabbit

Protein Name

E3 ISG15--protein ligase HERC5

Nucleotide Accession Number

NM_016323

Peptide Sequence

FHPEELKDVIVGNTDYDWKTFEKNARYEPGYNSSHPTIVMFWKAFHKLTL

Frequently Asked Questions

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