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HERC5 Antibody - middle region : Biotin (ARP43213_P050-Biotin)

Product Specifications

Gene Name

HECT and RLD domain containing E3 ubiquitin protein ligase 5

Gene Aliases

CEB1, CEBP1

Gene ID

51191

Swiss Prot

Q69G20

Accession Number

NP_057407

Host

Rabbit

Reactivity

Human, Rat, Cow, Horse, Pig, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human HERC5

Target

HERC5 is a member of the HERC family of ubiquitin ligases.It contains a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulates expression of HERC5 protein in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets.This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The gene lies in a cluster of HERC family genes on chromosome 4.

Partner Proteins

UBC; SMAD4; UBE2D1; gag; ISG15; TXNRD1; IRF3; HSPA8; CTNNB1; HERC5; SIRT7; STK38; PITX2; ERCC2; CCND1; CCNE1; CCNB1; CCNA2; NME2; CDKN1A

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

IHC, WB

Purification

Affinity Purified

Sample Type

HERC5 is supported by BioGPS gene expression data to be expressed in HEK293

Concentration

0.5 mg/ml

Homology

Cow: 79%; Horse: 79%; Human: 100%; Pig: 79%; Rabbit: 86%; Rat: 79%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

117kDa

References & Citations

Salon, C., (2007) Oncogene 26 (48), 6927-6936

Shipping Conditions

Wet Ice

Product Datasheet

Anti-HERC5 (ARP43213_P050-Biotin) antibody

Protein Length

1024

NCBI Gene Symbol

HERC5

NCBI GB Accession Number

HERC5

Host or Source

Rabbit

Protein Name

E3 ISG15--protein ligase HERC5

Nucleotide Accession Number

NM_016323

Peptide Sequence

FHPEELKDVIVGNTDYDWKTFEKNARYEPGYNSSHPTIVMFWKAFHKLTL

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