HERC5 Antibody - N-terminal region : Biotin (ARP43212_P050-Biotin)
Product Specifications
Gene Name
HECT and RLD domain containing E3 ubiquitin protein ligase 5
Gene Aliases
CEB1, CEBP1
Gene ID
51191
Swiss Prot
Q9UII4
Accession Number
NP_057407
Host
Rabbit
Reactivity
Human, Cow, Dog
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human HERC5
Target
HERC5 is a probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The gene lies in a cluster of HERC family genes on chromosome 4.
Partner Proteins
UBC; SMAD4; UBE2D1; gag; ISG15; TXNRD1; IRF3; HSPA8; CTNNB1; HERC5; SIRT7; STK38; PITX2; ERCC2; CCND1; CCNE1; CCNB1; CCNA2; NME2; CDKN1A
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Concentration
0.5 mg/ml
Homology
Cow: 86%; Dog: 79%; Human: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
117kDa
References & Citations
Salon, C., (2007) Oncogene 26 (48), 6927-6936
Shipping Conditions
Wet Ice
Protein Length
1024
NCBI Gene Symbol
HERC5
NCBI GB Accession Number
HERC5
Host or Source
Rabbit
Protein Name
E3 ISG15--protein ligase HERC5
Nucleotide Accession Number
NM_016323
Peptide Sequence
CLVAELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGNGGTRDQ
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