ANAPC5 Antibody - middle region : FITC (ARP43211_P050-FITC)

This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a.

ANAPC2; UBE2S; UBC; ANAPC4; HECW2; LATS2; PHF8; SOX2; PTEN; CDC27; BACH1; TRIM33; ANAPC7; ANAPC15; CDH1; CDC20; PAXIP1; MDC1; TP53BP1; NOTCH1; ANAPC1; ANAPC13; CDC16; CDC23; FBXO5; USP37; CUL4A; SH3KBP1; E2F1; SMARCAD1; MAPK6; Gm9174; Anapc5; Mad2l1; Anap

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.