RNF40 Antibody - C-terminal region : Biotin (ARP43165_T100-Biotin)

Product Specifications

Gene Name

Ring finger protein 40, E3 ubiquitin protein ligase

Gene Aliases

BRE1B, RBP95, STARING

Gene ID

9810

Swiss Prot

O75150

Accession Number

NP_055586

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human RNF40

Target

RNF40 contains a RING finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein was reported to interact with the tumor suppressor protein RB1. Studies of the rat counterpart suggested that this protein may function as an E3 ubiquitin-protein ligase, and facilitate the ubiquitination and degradation of syntaxin 1, which is an essential component of the neurotransmitter release machinery.The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein was reported to interact with the tumor suppressor protein RB1. Studies of the rat counterpart suggested that this protein may function as an E3 ubiquitin-protein ligase, and facilitate the ubiquitination and degradation of syntaxin 1, which is an essential component of the neurotransmitter release machinery.

Partner Proteins

UBE2A; UBC; SFR1; CCDC146; RNF20; AMOTL2; RNF40; UBE2I; UBE2B; MSL1; MSL2; PAF1; HIST2H2BE; CDK9; MDM2; USP15; HSP90AA1; NOTCH1; UBE2E1; RB1; ITSN1; CDC73; SUMO2; ATM; AR; TERF2; TERF1; WAC; ZNF451; TRIM51; UBE2L6; NCBP1; STX1A

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

IHC, WB

Sample Type

RNF40 is supported by BioGPS gene expression data to be expressed in HEK293T

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 85%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.