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FBXW11 Antibody - N-terminal region : Biotin (ARP43129_P050-Biotin)

Product Specifications

Gene Name

F-box and WD repeat domain containing 11

Gene Aliases

Hos, BTRC2, FBW1B, Fbw11, BTRCP2, FBXW1B, NEDJED

Gene ID

23291

Swiss Prot

Q9UKB1

Accession Number

NP_036432

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human FBXW11

Target

FBXW11 is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats.This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons.

Partner Proteins

ELMO2; NCKAP5L; USP37; CACHD1; ZNF395; TACC1; STK4; STK3; SKP1; REST; RELA; RAP1GAP; PFDN5; PFDN4; NRD1; NFKB2; NFKB1; NFE2L2; NEDD8; MAX; LRCH4; ILF3; FOXN2; HNRNPU; HIVEP2; HIVEP1; HCFC1; EZH2; DOCK1; DHX9; CTNNB1; CTNNA1; CLTC; CHD1; CDC34; CDC25B; CDC

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Sample Type

FBXW11 is strongly supported by BioGPS gene expression data to be expressed in 721_B

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

62kDa

References & Citations

Ewing, R.M., Mol. Syst. Biol. 3, 89 (2007)

Shipping Conditions

Wet Ice

Protein Length

542

NCBI Gene Symbol

FBXW11

NCBI GB Accession Number

FBXW11

Host or Source

Rabbit

Protein Name

F-box/WD repeat-containing protein 11

Nucleotide Accession Number

NM_012300

Peptide Sequence

CLQSMPSVRCLQISNGTSSVIVSRKRPSEGNYQKEKDLCIKYFDQWSESD

Frequently Asked Questions

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