STUB1 Antibody - N-terminal region : Biotin (ARP43058_P050-Biotin)
Product Specifications
Gene Name
STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
Gene Aliases
CHIP, SCA48, UBOX1, SCAR16, HSPABP2, NY-CO-7, SDCCAG7
Gene ID
10273
Swiss Prot
Q9UNE7
Accession Number
NP_005852
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Guinea Pig, Zebrafish
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human STUB1
Target
STUB1 modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. It has E3 ubiquitin-protein ligase activity and targets misfolded chaperone substrates towards proteasomal degradation. STUB1 mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation.
Partner Proteins
HSP90AA1; HSPA8; PCSK9; OLFM3; ATCAY; CCL28; UBE2Q1; TXN2; RUSC1; HSPA1B; FMR1; ERN1; STUB1; UBE2V1; UBE2N; UBE2D3; UBE2D1; UBC; TP53; MAPT; MAP3K11; SNAI2; BAG1; HSPA4L; CDC37; DNAJB6; BAG2; BAG3; BAG4; MLF2; HSP90AB1; HSPA4; HSPA2; HSPA1L; ENDOG; TXLNG
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
IHC, WB
Purification
Affinity Purified
Concentration
0.5 mg/ml
Homology
Cow: 100%; Guinea Pig: 100%; Human: 100%; Mouse: 100%; Rat: 100%; Zebrafish: 93%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
35kDa
References & Citations
Parsons, J.L., (2008) Mol. Cell 29 (4), 477-487
Shipping Conditions
Wet Ice
Protein Length
303
NCBI Gene Symbol
STUB1
NCBI GB Accession Number
STUB1
Host or Source
Rabbit
Protein Name
E3 ubiquitin-protein ligase CHIP
Nucleotide Accession Number
NM_005861
Peptide Sequence
MKGKEEKEGGARLGAGGGSPEKSPSAQELKEQGNRLFVGRKYPEAAACYG
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