UBE2D3 Antibody - N-terminal region : Biotin (ARP43009_P050-Biotin)

Product Specifications

Gene Name

Ubiquitin-conjugating enzyme E2D 3

Gene Aliases

UBC4/5, UBCH5C, E2 (17) KB3

Gene ID

7323

Swiss Prot

P61077

Accession Number

NP_003331

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Yeast, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human UBE2D3

Target

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE2D3 is a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase.The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. Multiple spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined.

Partner Proteins

NHLRC1; DTX2; TRIM63; RNF146; RNF26; RBX1; UBC; RNF5; RNF2; NEDD4; MID1; STUB1; TRIM39; OTUB1; MDM2; RNF111; TRIM33; PRPF19; RNF115; TRIM58; BTRC; MARCH7; NFKBIA; ARIH1; FBXW11; UBE2D3; PARK2; BRCA1; BARD1; UBE3A; MSL1; UBA1; CBLC; SMURF1; RNF130; UBA6; M

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

Purification

Affinity Purified

Sample Type

UBE2D3 is strongly supported by BioGPS gene expression data to be expressed in HEK293T, Jurkat, MCF7

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 92%; Rat: 100%; Yeast: 92%; Zebrafish: 92%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.