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RCHY1 Antibody - N-terminal region : HRP (ARP42973_P050-HRP)

Selected Variant

ARP42973_P050-HRP

Size: 100 µL

Product Specifications

Gene Name

Ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase

Gene Aliases

ZCHY, ARNIP, CHIMP, PIRH2, RNF199, ZNF363, PRO1996

Gene ID

25898

Swiss Prot

Q96PM5

Accession Number

NP_001008925

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit, Sheep

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human RCHY1

Target

RCHY1 has ubiquitin-protein ligase activity. This protein binds with p53 and promotes the ubiquitin-mediated proteosomal degradation of p53. This gene is oncogenic because loss of p53 function contributes directly to malignant tumor development. Transcription of this gene is regulated by p53.The protein encoded by this gene has ubiquitin-protein ligase activity. This protein binds with p53 and promotes the ubiquitin-mediated proteosomal degradation of p53. This gene is oncogenic because loss of p53 function contributes directly to malignant tumor development. Transcription of this gene is regulated by p53. Alternative splicing results in multiple transcript variants encoding different isoforms.

Partner Proteins

MEOX2; NOTCH2NL; UBASH3B; KRTAP9-2; LIMS2; SEMA4C; WDR74; ADAMTSL4; RCHY1; PGLS; KLHL41; MDM2; TAOK2; TP53; UBC; RNF2; HOXA2; YWHAE; CDK9; DCUN1D5; RILP; TMBIM1; CHD8; USP28; C19orf80; RBM38; NLK; TMEM14C; AIG1; SERTAD1; CHEK2; PRDX4; RAB11A; FADS6; TMEM1

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Sample Type

RCHY1 is strongly supported by BioGPS gene expression data to be expressed in Jurkat

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Horse: 100%; Human: 100%; Mouse: 93%; Pig: 93%; Rabbit: 100%; Rat: 100%; Sheep: 100%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

23kDa

References & Citations

Maruyama, S., Mol. Cell. Biochem. 307 (1-2), 73-82 (2008)

Shipping Conditions

Wet Ice

Protein Length

200

NCBI Gene Symbol

RCHY1

NCBI GB Accession Number

RCHY1

Host or Source

Rabbit

Protein Name

RING finger and CHY zinc finger domain-containing protein 1

Nucleotide Accession Number

NM_001008925

Peptide Sequence

KLYTCRLCHDNNEDHQLDRFKVKEVQCINCEKIQHAQQTCEECSTLFGEY

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