CALD1 Antibody - middle region : Biotin (ARP42685_P050-Biotin)
Product Specifications
Gene Name
Caldesmon 1
Gene Aliases
CDM, HCAD, LCAD, H-CAD, L-CAD, NAG22
Gene ID
800
Swiss Prot
Q05682
Accession Number
NP_004333
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human CALD1
Target
CALD1 is a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca (2+) -calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca (2+) -dependent inhibition of smooth muscle contraction. This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca (2+) -calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca (2+) -dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.
Partner Proteins
TP53; RPA3; RPA2; RPA1; PHAX; FH; EPB41L2; CSNK2A1; LRCH3; PRKACA; PAN2; UBC; HSP90AA1; CALM1; ACTN1; TINF2; POT1; ISG15; TERF1; ARRB1; Poc1b; Cep76; Sass6; Pafah1b1; TERF2; SHC1; CDK1; CALM3; GRB2
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Concentration
0.5 mg/ml
Homology
Cow: 86%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 93%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
63kDa
References & Citations
Yoshio, T., (2007) FEBS Lett. 581 (20), 3777-3782
Shipping Conditions
Wet Ice
Protein Length
538
NCBI Gene Symbol
CALD1
NCBI GB Accession Number
CALD1
Host or Source
Rabbit
Protein Name
Caldesmon
Nucleotide Accession Number
NM_004342
Peptide Sequence
FSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGD
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items