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EIF2AK1 Antibody - N-terminal region : Biotin (ARP42405_P050-Biotin)

Product Specifications

Gene Name

Eukaryotic translation initiation factor 2-alpha kinase 1

Gene Aliases

HCR, HRI, hHRI, LEMSPAD

Gene ID

27102

Swiss Prot

Q9BQI3

Accession Number

NP_055228

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human EIF2AK1

Target

EIF2AK1 acts at the level of translation initiation to downregulate protein synthesis in response to stress. The protein is a kinase that can be inactivated by hemin. Two transcript variants encoding different isoforms have been found for this gene.The HRI gene is localized to 7p22 where its 3' end slightly overlaps the 3' end of the gene JTV1. The two genes are transcribed from opposite strands. Studies in rat and rabbit suggest that the HRI gene product phosphorylates the alpha subunit of eukaryotic initiation factor 2. Its kinase activity is induced by low levels of heme and inhibited by the presence of heme. Sequence Note: The sequence AF181071.1 is a chimeric mRNA clone. Only the heme-regulated initiation factor 2-alpha kinase region was propagated into this RefSeq record.

Partner Proteins

MDM2; UBC; HSP90AA1; LIG4; CDC37; EIF2AK1; EIF2S1

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

WB, IHC

Purification

Affinity Purified

Sample Type

EIF2AK1 is strongly supported by BioGPS gene expression data to be expressed in HEK293T, HeLa

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 79%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

71kDa

References & Citations

Olsen, J.V., (2006) Cell 127 (3), 635-648

Shipping Conditions

Wet Ice

Product Datasheet

Anti-EIF2AK1 (ARP42405_P050-Biotin) antibody

Protein Length

630

NCBI Gene Symbol

EIF2AK1

NCBI GB Accession Number

EIF2AK1

Host or Source

Rabbit

Protein Name

Eukaryotic translation initiation factor 2-alpha kinase 1

Nucleotide Accession Number

NM_014413

Peptide Sequence

TCSDEFSSLRLHHNRAITHLMRSAKERVRQDPCEDISRIQKIRSREVALE

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