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PPP2R3B Antibody - C-terminal region : Biotin (ARP42371_P050-Biotin)

Product Specifications

Gene Name

Protein phosphatase 2, regulatory subunit B'', beta

Gene Aliases

PR48, PR70, NYREN8, PPP2R3L, PPP2R3LY

Gene ID

28227

Swiss Prot

Q9Y5P8

Accession Number

NP_037371

Host

Rabbit

Reactivity

Human, Rat, Cow, Dog

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human PPP2R3B

Target

Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. PPP2R3B belongs to the B'' family. The B'' family has been further divided into subfamilies. PPP2R3B belongs to the beta subfamily of regulatory subunit B''.Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the beta subfamily of regulatory subunit B''. Alternative splicing results in multiple transcript variants encoding different isoforms.

Partner Proteins

DUSP12; UBC; PPP2R1A; CDC6; PPP2R1B; PPP2CA

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 86%; Dog: 93%; Human: 100%; Rat: 75%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

65kDa

References & Citations

Stevens, I., (2003) Eur. J. Biochem. 270 (2), 376-387

Shipping Conditions

Wet Ice

Protein Length

575

NCBI Gene Symbol

PPP2R3B

NCBI GB Accession Number

PPP2R3B

Host or Source

Rabbit

Protein Name

Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta

Nucleotide Accession Number

NM_013239

Peptide Sequence

ELSDWEKYAAEEYDILVAEETAGEPWEDGFEAELSPVEQKLSALRSPLAQ

Subunit

B

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