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CES2 Antibody - C-terminal region : FITC (ARP42158_P050-FITC)

Product Specifications

Gene Name

Carboxylesterase 2

Gene Aliases

ICE, CE-2, PCE-2, CES2A1

Gene ID

8824

Swiss Prot

O00748

Accession Number

NP_003860

Host

Rabbit

Reactivity

Human, Mouse, Rat, Dog, Guinea Pig

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human CES2

Target

Carboxylesterase 2 is a member of a large multigene family. The enzymes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolize long-chain fatty acid esters and thioesters. The specific function of this enzyme has not yet been determined; however, it is speculated that carboxylesterases may play a role in lipid metabolism and/or the blood-brain barrier system.Carboxylesterase 2 is a member of a large multigene family. The enzymes encoded by these genes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolize long-chain fatty acid esters and thioesters. The specific function of this enzyme has not yet been determined; however, it is speculated that carboxylesterases may play a role in lipid metabolism and/or the blood-brain barrier system. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Clonality

Polyclonal

Conjugation

FITC: Fluorescein Isothiocyanate

Type

Polyclonal Antibody

Applications

WB, IHC

Purification

Affinity Purified

Sample Type

CES2 is strongly supported by BioGPS gene expression data to be expressed in HepG2

Concentration

0.5 mg/ml

Homology

Dog: 83%; Guinea Pig: 83%; Human: 100%; Mouse: 83%; Rat: 83%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

69kDa

References & Citations

Kimura, K., (2006) Genome Res. 16 (1), 55-65

Shipping Conditions

Wet Ice

Protein Length

623

NCBI Gene Symbol

CES2

NCBI GB Accession Number

CES2

Host or Source

Rabbit

Protein Name

Cocaine esterase

Nucleotide Accession Number

NM_003869

Peptide Sequence

HWPLFDQEEQYLQLNLQPAVGRALKAHRLQFWKKALPQKIQELEEPEERH

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