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CES2 Antibody - C-terminal region : Biotin (ARP42158_P050-Biotin)

Product Specifications

Gene Name

Carboxylesterase 2

Gene Aliases

ICE, CE-2, PCE-2, CES2A1

Gene ID

8824

Swiss Prot

O00748

Accession Number

NP_003860

Host

Rabbit

Reactivity

Human, Mouse, Rat, Dog, Guinea Pig

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human CES2

Target

Carboxylesterase 2 is a member of a large multigene family. The enzymes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolize long-chain fatty acid esters and thioesters. The specific function of this enzyme has not yet been determined; however, it is speculated that carboxylesterases may play a role in lipid metabolism and/or the blood-brain barrier system.Carboxylesterase 2 is a member of a large multigene family. The enzymes encoded by these genes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolize long-chain fatty acid esters and thioesters. The specific function of this enzyme has not yet been determined; however, it is speculated that carboxylesterases may play a role in lipid metabolism and/or the blood-brain barrier system. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

WB, IHC

Purification

Affinity Purified

Sample Type

CES2 is strongly supported by BioGPS gene expression data to be expressed in HepG2

Concentration

0.5 mg/ml

Homology

Dog: 83%; Guinea Pig: 83%; Human: 100%; Mouse: 83%; Rat: 83%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

69kDa

References & Citations

Kimura, K., (2006) Genome Res. 16 (1), 55-65

Shipping Conditions

Wet Ice

Protein Length

623

NCBI Gene Symbol

CES2

NCBI GB Accession Number

CES2

Host or Source

Rabbit

Protein Name

Cocaine esterase

Nucleotide Accession Number

NM_003869

Peptide Sequence

HWPLFDQEEQYLQLNLQPAVGRALKAHRLQFWKKALPQKIQELEEPEERH

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