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LEFTY2 Antibody - N-terminal region : Biotin (ARP42107_P050-Biotin)

Product Specifications

Gene Name

Left-right determination factor 2

Gene Aliases

EBAF, LEFTA, TGFB4, LEFTYA

Gene ID

7044

Swiss Prot

O00292

Accession Number

NP_003231

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Horse, Pig

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human LEFTY2

Target

LEFTY2 is a member of the TGF-beta family of proteins. The protein is secreted and plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in its gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of its gene in the endometrium.This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene.

Partner Proteins

ACSS3

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

IHC, WB

Purification

Affinity Purified

Sample Type

LEFTY2 is supported by BioGPS gene expression data to be expressed in RPMI 8226

Concentration

0.5 mg/ml

Homology

Cow: 79%; Horse: 93%; Human: 100%; Mouse: 79%; Pig: 86%; Rat: 83%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

40kDa

References & Citations

Cornet, P.B., (2005) J. Clin. Endocrinol. Metab. 90 (2), 1001-1011

Shipping Conditions

Wet Ice

Protein Length

366

NCBI Gene Symbol

LEFTY2

NCBI GB Accession Number

LEFTY2

Host or Source

Rabbit

Protein Name

Left-right determination factor 2

Nucleotide Accession Number

NM_003240

Peptide Sequence

MWPLWLCWALWVLPLAGPGAALTEEQLLGSLLRQLQLSEVPVLDRADMEK

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