DLAT Antibody - C-terminal region: HRP (ARP41995_P050-HRP)
Product Specifications
Gene Name
Dihydrolipoamide S-acetyltransferase
Gene Aliases
E2, PBC, DLTA, PDCE2, PDC-E2
Gene ID
1737
Swiss Prot
Q86YI5
Accession Number
NP_001922
Host
Rabbit
Reactivity
Human, Mouse, Rat, Dog, Pig, Zebrafish
Immunogen
The immunogen is a synthetic peptide directed towards the C terminal region of human DLAT
Target
DLAT is dihydrolipoamide acetyltransferase, the E2 subunit of the mammalian pyruvate dehydrogenase complex of the inner mitochondrial membrane. Patients with primary biliary cirrhosis show autoantibodies to DLAT.The DLAT gene encodes dihydrolipoamide acetyltransferase (EC 2.3.1.12), the E2 subunit of the mammalian pyruvate dehydrogenase complex (PDC; EC 1.2.4.1) of the inner mitochondrial membrane. Patients with primary biliary cirrhosis (PBC; MIM 109720) show autoantibodies to DLAT.[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-2696 AK057299.1 1-2696 2697-3933 BC039084.1 2066-3302 3934-4322 DB551427.1 98-486
Partner Proteins
MDM2; UBC; ADRB2; PRKD3; PDHX; MMGT1; MRPL1; ACAD9; SYNCRIP; PDHA2; PDHA1; OGDH; NDUFS4; HSPA1L; DLD; COX5B; COPS5; CUL1; SIRT7; TSG101; KIAA0101; PSMA3; PDK4; PDK3; PDK2; PDK1; PDHB
Clonality
Polyclonal
Conjugation
HRP: Horseradish Peroxidase
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Sample Type
DLAT is strongly supported by BioGPS gene expression data to be expressed in HepG2
Concentration
0.5 mg/mL
Homology
Dog: 100%; Human: 100%; Mouse: 100%; Pig: 92%; Rat: 100%; Zebrafish: 92%
Format
Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
69kDa
Shipping Conditions
Wet Ice
Protein Length
647
NCBI Gene Symbol
DLAT
Protein Name
Dihydrolipoamide S-acetyltransferase EMBL AAH39084.1
Nucleotide Accession Number
NM_001931
Curated Selection
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