DAB2 Antibody - N-terminal region : Biotin (ARP41937_P050-Biotin)

This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Fcho2; CPSF7; SMURF2; YLPM1; C14orf166; ACOT9; CPSF6; SF3B2; MALT1; HSPH1; SEC23B; SEC24B; NUP155; CDC16; TRIO; TFAP2A; AURKA; PYCR1; PRDX1; MYO6; HSPA1B; HNRNPL; GRB2; FN1; CLTC; AP2M1; CFTR; CCNT1; ACTB; AHCY; AP2B1; AP2A2; AP2A1; DYT10; ATXN1L; SH3KBP1

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.