F2 Antibody - middle region : Biotin (ARP41757_P050-Biotin)
Product Specifications
Gene Name
Coagulation factor II (thrombin)
Gene Aliases
PT, THPH1, RPRGL2
Gene ID
2147
Swiss Prot
P00734
Accession Number
NP_000497
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Sheep, Zebrafish
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human F2
Target
Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life.Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Partner Proteins
ST13; FN1; DDIT3; ALB; F11; PROZ; ITGA2B; SERPING1; HGFAC; AKR7A2; CPB2; F2RL3; F2RL2; SERPINA5; SERPINB8; AANAT; F2RL1; F9; F8; GP1BA; KNG1; F5; C6; PLAU; THBS1; THBD; F2R; SERPINE2; F2; PROS1; AMBP; PROC; GP5; SERPINE1; SERPINB6; SPP1; IGFBP5; IGFBP3; S
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
IHC, WB
Purification
Affinity Purified
Concentration
0.5 mg/ml
Homology
Cow: 92%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rat: 100%; Sheep: 93%; Zebrafish: 77%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
70kDa
References & Citations
Rossi, E., (2008) Thromb. Haemost. 99 (6), 1030-1034
Shipping Conditions
Wet Ice
Protein Length
622
NCBI Gene Symbol
F2
NCBI GB Accession Number
F2
Host or Source
Rabbit
Protein Name
Prothrombin
Nucleotide Accession Number
NM_000506
Peptide Sequence
ISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLE
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