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F2 Antibody - middle region : Biotin (ARP41757_P050-Biotin)

Product Specifications

Gene Name

Coagulation factor II (thrombin)

Gene Aliases

PT, THPH1, RPRGL2

Gene ID

2147

Swiss Prot

P00734

Accession Number

NP_000497

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Sheep, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human F2

Target

Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life.Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Partner Proteins

ST13; FN1; DDIT3; ALB; F11; PROZ; ITGA2B; SERPING1; HGFAC; AKR7A2; CPB2; F2RL3; F2RL2; SERPINA5; SERPINB8; AANAT; F2RL1; F9; F8; GP1BA; KNG1; F5; C6; PLAU; THBS1; THBD; F2R; SERPINE2; F2; PROS1; AMBP; PROC; GP5; SERPINE1; SERPINB6; SPP1; IGFBP5; IGFBP3; S

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

IHC, WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 92%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rat: 100%; Sheep: 93%; Zebrafish: 77%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

70kDa

References & Citations

Rossi, E., (2008) Thromb. Haemost. 99 (6), 1030-1034

Shipping Conditions

Wet Ice

Protein Length

622

NCBI Gene Symbol

F2

NCBI GB Accession Number

F2

Host or Source

Rabbit

Protein Name

Prothrombin

Nucleotide Accession Number

NM_000506

Peptide Sequence

ISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLE

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