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STK11 Antibody - N-terminal region : Biotin (ARP41743_T100-Biotin)

Product Specifications

Gene Name

Serine/threonine kinase 11

Gene Aliases

PJS, LKB1, hLKB1

Gene ID

6794

Swiss Prot

Q15831

Accession Number

NP_000446

Host

Rabbit

Reactivity

Human, Mouse, Rat, Dog, Guinea Pig, Horse, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human STK11

Target

STK11is a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in its gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms.This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

Partner Proteins

SPDEF; SIRT1; PRKAA1; ETV4; CDC37; HSP90AA1; TP63; Eif2b1; Ap2m1; SNRK; APP; TNIP2; SIK1; STRADA; STUB1; UBE2D2; MARK2; GSK3B; STRADB; CAB39; KIF23; USP11; SMARCC1; SMARCA4; LIMS1; HSPA1A; FKBP5; RPAP3; MARK4; UBC; CAB39L; WDR48; RPS6KB1; MOB4; MARK1; RPS

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

IHC, WB

Sample Type

STK11 is supported by BioGPS gene expression data to be expressed in Jurkat

Concentration

0.5 mg/ml

Homology

Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rat: 100%; Zebrafish: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

48kDa

References & Citations

Xie, Z., (2006) J. Biol. Chem. 281 (10), 6366-6375

Shipping Conditions

Wet Ice

Protein Length

433

NCBI Gene Symbol

STK11

NCBI GB Accession Number

STK11

Host or Source

Rabbit

Protein Name

Serine/threonine-protein kinase STK11

Nucleotide Accession Number

NM_000455

Peptide Sequence

TLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLVDVLYNE

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