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KRT10 Antibody - N-terminal region : Biotin (ARP41730_P050-Biotin)

Product Specifications

Gene Name

Keratin 10

Gene Aliases

BIE, EHK, K10, KPP, BCIE, CK10

Gene ID

3858

Swiss Prot

P13645

Accession Number

NP_000412

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human KRT10

Target

KRT10 is a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in the gene encoding KRT10 are associated with epidermolytic hyperkeratosis. This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Partner Proteins

UBC; Fbxl16; ADRB2; PAN2; Nphp4; Iqcb1; Cep290; Nphp1; Invs; VCAM1; SRC; ITGA4; FN1; ALB; MAGOH; TRAF3IP1; EIF4A3; AHNAK2; KRT2; KRT1; ELAVL1; UBASH3B; SHC1; PIK3R2; INPPL1; GRB2; EPS15; CRK; AP2M1; CBL; NEDD8; CAND1; DCUN1D1; COPS5; COPS6; CUL1; CUL2; CU

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 93%; Dog: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 86%; Rabbit: 100%; Rat: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

59kDa

References & Citations

Tsubota, A., (2008) J. Invest. Dermatol. 128 (7), 1648-1652

Shipping Conditions

Wet Ice

Protein Length

584

NCBI Gene Symbol

KRT10

NCBI GB Accession Number

KRT10

Host or Source

Rabbit

Protein Name

Keratin, type I cytoskeletal 10

Nucleotide Accession Number

NM_000421

Peptide Sequence

EKVTMQNLNDRLASYLDKVRALEESNYELEGKIKEWYEKHGNSHQGEPRD

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