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UROD Antibody - N-terminal region : HRP (ARP41724_T100-HRP)

Selected Variant

ARP41724_T100-HRP

Size: 100 µL

Product Specifications

Gene Name

Uroporphyrinogen decarboxylase

Gene Aliases

PCT, UPD

Gene ID

7389

Swiss Prot

P06132

Accession Number

NP_000365

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Sheep, Yeast, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human UROD

Target

UROD is the fifth enzyme of the heme biosynthetic pathway. This enzyme is responsible for catalyzing the conversion of uroporphyrinogen to coproporphyrinogen through the removal of four carboxymethyl side chains. Mutations and deficiency in this enzyme are known to cause familial porphyria cutanea tarda and hepatoerythropoetic porphyria.This gene encodes the fifth enzyme of the heme biosynthetic pathway. This enzyme is responsible for catalyzing the conversion of uroporphyrinogen to coproporphyrinogen through the removal of four carboxymethyl side chains. Mutations and deficiency in this enzyme are known to cause familial porphyria cutanea tarda and hepatoerythropoetic porphyria.

Partner Proteins

FAM84B; UBC; CHRAC1; MTAP; BAG3; NME1; FAF1; HMGXB4; VIM; CHD3; EGFR; UROD

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

IHC, WB

Sample Type

UROD is strongly supported by BioGPS gene expression data to be expressed in HepG2

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 92%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 93%; Rat: 100%; Sheep: 100%; Yeast: 100%; Zebrafish: 83%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

40kDa

References & Citations

Harraway, J.R., Ann. Clin. Biochem. 43 (PT 1), 80-82 (2006)

Shipping Conditions

Wet Ice

Protein Length

367

NCBI Gene Symbol

UROD

NCBI GB Accession Number

UROD

Host or Source

Rabbit

Protein Name

Uroporphyrinogen decarboxylase

Nucleotide Accession Number

NM_000374

Peptide Sequence

VPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVP

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