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GAMT Antibody - N-terminal region : HRP (ARP41684_P050-HRP)

Selected Variant

ARP41684_P050-HRP

Size: 100 µL

Product Specifications

Gene Name

Guanidinoacetate N-methyltransferase

Gene Aliases

PIG2, CCDS2, TP53I2, HEL-S-20

Gene ID

2593

Swiss Prot

Q14353

Accession Number

NP_000147

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Guinea Pig, Pig

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human GAMT

Target

GAMT is a methyltransferase that converts guanidoacetate to creatine, using S-adenosylmethionine as the methyl donor. Defects in its gene have been implicated in neurologic syndromes and muscular hypotonia, probably due to creatine deficiency and accumulation of guanidinoacetate in the brain of affected individuals.The protein encoded by this gene is a methyltransferase that converts guanidoacetate to creatine, using S-adenosylmethionine as the methyl donor. Defects in this gene have been implicated in neurologic syndromes and muscular hypotonia, probably due to creatine deficiency and accumulation of guanidinoacetate in the brain of affected individuals. Two transcript variants encoding different isoforms have been described for this gene.

Partner Proteins

FOS; CSNK2B; UBC; TERF2IP; POT1; TERF1

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Sample Type

GAMT is supported by BioGPS gene expression data to be expressed in Jurkat

Concentration

0.5 mg/ml

Homology

Cow: 92%; Guinea Pig: 85%; Human: 100%; Mouse: 92%; Pig: 92%; Rat: 85%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

26kDa

References & Citations

Komoto, J., (1999) Acta Crystallogr. D Biol. Crystallogr. 55 (11), 1928-1929

Shipping Conditions

Wet Ice

Protein Length

236

NCBI Gene Symbol

GAMT

NCBI GB Accession Number

GAMT

Host or Source

Rabbit

Protein Name

Guanidinoacetate N-methyltransferase

Nucleotide Accession Number

NM_000156

Peptide Sequence

MSAPSATPIFAPGENCSPAWGAAPAAYDAADTHLRILGKPVMERWETPYM

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