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ALAS2 Antibody - C-terminal region : HRP (ARP41659_P050-HRP)

Selected Variant

ARP41659_P050-HRP

Size: 100 µL

Product Specifications

Gene Name

Aminolevulinate, delta-, synthase 2

Gene Aliases

ASB, ANH1, XLSA, ALASE, XLDPP, XLEPP, ALAS-E, SIDBA1

Gene ID

212

Swiss Prot

P22557

Accession Number

NP_001033056

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Sheep, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human ALAS2

Target

ALAS2 specifies an erythroid-specific mitochondrially located enzyme. The protein catalyzes the first step in the heme biosynthetic pathway. Defects in its gene cause X-linked pyridoxine-responsive sideroblastic anemia. Alternatively spliced transcript variants encoding different isoforms have been identified.The product of this gene specifies an erythroid-specific mitochondrially located enzyme. The encoded protein catalyzes the first step in the heme biosynthetic pathway. Defects in this gene cause X-linked pyridoxine-responsive sideroblastic anemia. Alternatively spliced transcript variants encoding different isoforms have been identified.

Partner Proteins

BANP; GRB2; SUCLA2; RABGGTB

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Goat: 79%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 79%; Zebrafish: 85%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

60kDa

References & Citations

Lee, P.L., (2006) Blood Cells Mol. Dis. 36 (2), 292-297

Shipping Conditions

Wet Ice

Protein Length

550

NCBI Gene Symbol

ALAS2

NCBI GB Accession Number

ALAS2

Host or Source

Rabbit

Protein Name

5-aminolevulinate synthase, erythroid-specific, mitochondrial

Nucleotide Accession Number

NM_001037967

Peptide Sequence

PTVPRGEELLRLAPSPHHSPQMMEDFVEKLLLAWTAVGLPLQDVSVAACN

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