LBP Antibody - C-terminal region : Biotin (ARP41546_P050-Biotin)

Product Specifications

Gene Name

Lipopolysaccharide binding protein

Gene Aliases

BPIFD2

Gene ID

3929

Swiss Prot

P18428

Accession Number

NP_004130

Host

Rabbit

Reactivity

Human, Cow, Horse, Pig

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human LBP

Target

LBP is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP) .The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP) . Finally, this gene is found on chromosome 20, immediately downstream of the BPI gene.

Partner Proteins

TSC22D4; PYCRL; TRA2A; PRDX4; SETD1A; CBFA2T2; BAG6; PSMA3; SMAD3; HSPB1; FTH1; C4BPA; BST1; CAMP; APOA1; RPS21; CD14; CFHR1; IRF6

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

WB, IHC

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 86%; Horse: 85%; Human: 100%; Pig: 79%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.