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DES Antibody - middle region : FITC (ARP41483_P050-FITC)

Product Specifications

Gene Name

Desmin

Gene Aliases

CSM1, CSM2, CDCD3, LGMD1D, LGMD1E, LGMD2R

Gene ID

1674

Swiss Prot

P17661

Accession Number

NP_001918

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human DES

Target

DES is a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in its gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies.This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Partner Proteins

PPP1R18; UBE2I; EHHADH; TRIM63; TRIM55; UBC; YWHAQ; MAPKAPK2; CAPN1; MLH1; AURKB; HADHB; MYL6; JUP; HSP90AA5P; HNRNPUL1; CCT7; SNRNP70; RPL29; RPL17; UBD; CRYAB; SHBG; SP1; ITSN1; NEB; PLEKHA5; SYNC; TRIM7; SYNM; ROCK1; PKD1; SPTAN1; S100B; S100A1; DSP

Clonality

Polyclonal

Conjugation

FITC: Fluorescein Isothiocyanate

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

53kDa

References & Citations

Pica, E.C., (2008) Neuromuscul. Disord. 18 (2), 178-182

Shipping Conditions

Wet Ice

Protein Length

470

NCBI Gene Symbol

DES

NCBI GB Accession Number

DES

Host or Source

Rabbit

Protein Name

Desmin

Nucleotide Accession Number

NM_001927

Peptide Sequence

MALDVEIATYRKLLEGEESRINLPIQTYSALNFRETSPEQRGSEVHTKKT

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