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MSH2 Antibody - N-terminal region : FITC (ARP41350_T100-FITC)

Selected Variant

ARP41350_T100-FITC

Size: 100 µL

Product Specifications

Gene Name

MutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)

Gene Aliases

FCC1, COCA1, HNPCC, LCFS2, hMSH2, HNPCC1, MMRCS2

Gene ID

4436

Swiss Prot

P43246

Accession Number

AAY15096

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Yeast, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human MSH2

Target

MSH2 was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC) . When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC.

Partner Proteins

ESR1; BRCA1; SUMO2; RPA3; RPA2; RPA1; REV1; POLK; DPYSL3; ATP6V1B2; CUL2; XRCC5; SUPT5H; STAT3; ST13; PDE3A; NRD1; JUP; XRCC6; SEC23A; HDAC6; PCNA; MSH3; MSH6; ERCC4; ERCC1; gag-pol; UBC; SUPT16H; SEPT9; SRSF10; SRSF11; SART1; SMARCA5; TOP2B; SRSF7; SRSF5

Clonality

Polyclonal

Conjugation

FITC: Fluorescein Isothiocyanate

Type

Polyclonal Antibody

Applications

WB

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 93%; Rabbit: 100%; Rat: 100%; Yeast: 85%; Zebrafish: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

64kDa

References & Citations

Hoss, M. EMBO J. (1999) 18 (13), 3868-3875

Shipping Conditions

Wet Ice

Protein Length

586

NCBI Gene Symbol

MSH2

NCBI GB Accession Number

MSH2

Host or Source

Rabbit

Protein Name

DNA mismatch repair protein Msh2

Nucleotide Accession Number

NM_000251

Peptide Sequence

KMSAVDGQRQVGVGYVDSIQRKLGLCEFPDNDQFSNLEALLIQIGPKECV

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