DCP2 Antibody - C-terminal region : Biotin (ARP41150_P050-Biotin)

Product Specifications

Gene Name

DCP2 decapping enzyme homolog (S. cerevisiae)

Gene Aliases

NUDT20

Gene ID

167227

Swiss Prot

Q8IU60

Accession Number

NP_689837

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human DCP2

Target

DCP2 is necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. DCP2 removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. It has higher activity towards mRNAs that lack a poly (A) tail, but has no activity towards a cap structure lacking a RNA moiety.DCP2 is a key component of an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005 [PubMed 16364915]) .[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-539 AY135173.1 1-539 540-1992 AK090564.1 481-1933 1993-8947 AC008536.7 154323-161277

Partner Proteins

FAM96B; DCP1A; UBC; EDC4; DCP1B; SFXN2; ANGEL2; ARMCX5; DARS2; ELP3; QPCTL; GTPBP2; TRMT2A; FBXO3; INTS7; POLD3; GFPT2; AP1M1; SQSTM1; IKBKAP; TRRAP; TARS; ABCE1; PHKB; PGM3; PFKM; IDE; GLUD1; GGT7; GGCX; GFPT1; GARS; FANCD2; EIF5A; SLC25A10; CAPN2; NAGK

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

Purification

Affinity Purified

Sample Type

DCP2 is supported by BioGPS gene expression data to be expressed in Jurkat

Concentration

0.5 mg/ml

Homology

Cow: 86%; Dog: 93%; Guinea Pig: 86%; Horse: 100%; Human: 100%; Mouse: 79%; Pig: 100%; Rat: 86%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.