EXOSC6 Antibody - N-terminal region : Biotin (ARP41086_P050-Biotin)

Product Specifications

Gene Name

Exosome component 6

Gene Aliases

P11, EAP4, MTR3, Mtr3p, hMtr3p

Gene ID

118460

Swiss Prot

Q5RKV6

Accession Number

NP_478126

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Pig, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human EXOSC6

Target

EXOSC6 constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly (A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation.This gene product constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly (A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation.

Partner Proteins

CEP250; DCP1B; EXOSC6; CHPF; MIF4GD; XRN1; NDUFA13; MRPL4; EXOSC1; MRPS18B; UPF2; RAB3GAP2; SKIV2L2; GSE1; EXOSC7; EXOSC8; ZFP36; TUFM; EXOSC10; MAN2C1; ESRRA; C1QBP; AICDA; DIS3L; EXOSC4; EXOSC3; CUL3; ELAVL1; HDGF; UBC; EXOSC5; DNAJC30; MOCS3; MPP6; EXO

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rat: 100%; Zebrafish: 86%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.