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FIP1L1 Antibody - C-terminal region : FITC (ARP41031_P050-FITC)

Selected Variant

ARP41031_P050-FITC

Size: 100 µL

Product Specifications

Gene Name

FIP1 like 1 (S. cerevisiae)

Gene Aliases

Rhe, FIP1, hFip1

Gene ID

81608

Swiss Prot

Q6UN15

Accession Number

NP_112179

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human FIP1L1

Target

FIP1L1 is a component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly (A) polymerase and other factors to bring about cleavage and poly (A) addition. FIP1L1 contributes to poly (A) site recognition and stimulates poly (A) addition. It binds to U-rich RNA sequence elements surrounding the poly (A) site. FIP1L1 may act to tether poly (A) polymerase to the CPSF complex.

Partner Proteins

ZMYND19; CPSF4; NAA10; SGTA; GOLGA2; STAU1; UBC; WWOX; SUZ12; RNF2; EZH2; PRMT6; PRMT2; CLK2; HDAC9; CSNK2A1; LIG4; WDR33; CPSF2; CPSF3; CPSF1; NUP153; APP; COPS5; HNRNPA1; SRRM2; RNPS1

Clonality

Polyclonal

Conjugation

FITC: Fluorescein Isothiocyanate

Type

Polyclonal Antibody

Applications

IHC, WB

Purification

Affinity Purified

Sample Type

FIP1L1 is supported by BioGPS gene expression data to be expressed in Jurkat

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%; Zebrafish: 86%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

65kDa

References & Citations

Zhao, X., (2005) J. Virol. 79 (7), 4270-4288

Shipping Conditions

Wet Ice

Protein Length

594

NCBI Gene Symbol

FIP1L1

NCBI GB Accession Number

FIP1L1

Host or Source

Rabbit

Protein Name

Pre-mRNA 3'-end-processing factor FIP1

Nucleotide Accession Number

NM_030917

Peptide Sequence

EYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGD

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