UPF2 Antibody - N-terminal region : HRP (ARP40814_P050-HRP)

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD) . When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene; both variants encode the same protein.

PUF60; UBC; UPF1; LGR4; MIF; LDHA; KRT18; ITGB1; HMGA1; ZBTB48; HBZ; ENO1; E4F1; CYBA; CALR; BLM; ATP1B3; ART4; DCP1B; DCP2; COMTD1; EXOSC6; GADD45GIP1; ZGPAT; MAP1LC3B; ZNF408; CENPU; WNK1; RSRC2; MRPL40; ZNF44; EXOSC1; MTERF3; GLTSCR2; NOB1; RRP7A; SERB

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.