DIS3 Antibody - N-terminal region : FITC (ARP40793_P050-FITC)
Product Specifications
Gene Name
DIS3 mitotic control homolog (S. cerevisiae)
Gene Aliases
RRP44, dis3p, EXOSC11, KIAA1008, 2810028N01Rik
Gene ID
22894
Swiss Prot
Q9Y2L1
Accession Number
NP_055768
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human DIS3
Target
DIS3, belonging to the ribonuclease II (RNB) family, has a 3'-5' exonuclease activity. It is a catalytic component of the exosome 3'->5' exoribonuclease complex required for the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA and for mRNA decay. The protein is implicated in mitotic control and essential for cell division and spore germination. It may be involved in regulating protein dephosphorylation during mitosis.
Partner Proteins
SUMO2; UBC; TWF1; NTMT1; EXOSC8; EXOSC10; AICDA; WDR1; STXBP3; PPP5C; SH3PXD2B; EXOSC5; EXOSC4; EXOSC1; EXOSC3; SKIV2L2; EXOSC2; EXOSC7; DIS3; EXOSC9; CUL3; CUL5; SIRT7; BABAM1; EXOSC6; MPP6; ZBTB17
Clonality
Polyclonal
Conjugation
FITC: Fluorescein Isothiocyanate
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Concentration
0.5 mg/ml
Homology
Cow: 79%; Dog: 93%; Guinea Pig: 79%; Horse: 93%; Human: 100%; Mouse: 85%; Pig: 93%; Rabbit: 86%; Rat: 86%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
109kDa
References & Citations
Andersen, J.S., (2005) Nature 433 (7021), 77-83
Shipping Conditions
Wet Ice
Protein Length
958
NCBI Gene Symbol
DIS3
NCBI GB Accession Number
DIS3
Host or Source
Rabbit
Protein Name
Exosome complex exonuclease RRP44
Nucleotide Accession Number
NM_014953
Peptide Sequence
DIVAVELLPKSQWVAPSSVVLHDEGQNEEDVEKEEETERMLKTAVSEKML
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