CPSF1 Antibody - middle region : Biotin (ARP40741_P050-Biotin)
Product Specifications
Gene Name
Cleavage and polyadenylation specific factor 1, 160kDa
Gene Aliases
MYP27, CPSF160, P/cl.18, HSU37012
Gene ID
29894
Swiss Prot
Q10570
Accession Number
NP_037423
Host
Rabbit
Reactivity
Human, Rat, Horse
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human CPSF1
Target
CPSF1 is a component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly (A) polymerase and other factors to bring about cleavage and poly (A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction.
Partner Proteins
REL; RBBP6; UBC; STAU1; LGR4; WWOX; RPA3; RPA2; RPA1; EED; EZH2; NEDD4; TARDBP; ICK; CLK2; HDAC6; NPM1; IL7R; HMOX1; TUT1; FIP1L1; RNPC3; WDR33; CPSF2; MED8; CPSF3; GTF3C3; POLR2A; COPS6; CUL3; SIRT7; SMARCAD1; CSTF2T; PAPOLA; CSTF3; GLIS2; RRAGA; TBP; TA
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Concentration
0.5 mg/ml
Homology
Horse: 79%; Human: 100%; Rat: 77%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
161kDa
References & Citations
Beausoleil, S.A., (2004) Proc. Natl. Acad. Sci. U.S.A. 101 (33), 12130-12135
Shipping Conditions
Wet Ice
Protein Length
1443
NCBI Gene Symbol
CPSF1
NCBI GB Accession Number
CPSF1
Host or Source
Rabbit
Protein Name
Cleavage and polyadenylation specificity factor subunit 1
Nucleotide Accession Number
NM_013291
Peptide Sequence
GCYDMWTVIAPVRKEEEDNPKGEGTEQEPSTTPEADDDGRRHGFLILSRE
Subunit
1
Curated Selection
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