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KHDRBS1 Antibody - N-terminal region : HRP (ARP40665_P050-HRP)

Selected Variant

ARP40665_P050-HRP

Size: 100 µL

Product Specifications

Gene Name

KH domain containing, RNA binding, signal transduction associated 1

Gene Aliases

P62, p68, Sam68

Gene ID

10657

Swiss Prot

Q07666

Accession Number

NP_006550

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human KHDRBS1

Target

KHDRBS1 recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, KHDRBS1 functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. KHDRBS1 play a role in G2-M progression in the cell cycle. It represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. KHDRBS1 also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export.

Partner Proteins

UBC; LGR4; DROSHA; RPA3; RPA2; RPA1; RNF2; EZH2; BMI1; SUZ12; rev; APBB1; GAS7; WBP4; RASA1; SRC; CSK; PLCG1; PIK3R1; IRS1; CD81; TNFRSF1A; KHDRBS3; GPHN; RBM7; PIK3R3; HNRNPK; GRB2; EFEMP1; DHX9; DDX5; CRKL; CIRBP; ACTB; AZIN1; RBMX; AGO1; POT1; RBFOX2

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

IHC, WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 93%; Rabbit: 100%; Rat: 100%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

48kDa

References & Citations

Duran, A., (2008) Cancer Cell 13 (4), 343-354

Shipping Conditions

Wet Ice

Protein Length

443

NCBI Gene Symbol

KHDRBS1

NCBI GB Accession Number

KHDRBS1

Host or Source

Rabbit

Protein Name

KH domain-containing, RNA-binding, signal transduction-associated protein 1

Nucleotide Accession Number

NM_006559

Peptide Sequence

LPELMAEKDSLDPSFTHAMQLLTAEIEKIQKGDSKKDDEENYLDLFSHKN

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