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SMNDC1 Antibody - C-terminal region : Biotin (ARP40611_P050-Biotin)

Product Specifications

Gene Name

Survival motor neuron domain containing 1

Gene Aliases

SMNR, SPF30, TDRD16C

Gene ID

10285

Swiss Prot

Q6DEY1

Accession Number

NP_005862

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human SMNDC1

Target

This gene is a paralog of SMN1 gene, which encodes the survival motor neuron protein, mutations in which are cause of autosomal recessive proximal spinal muscular atrophy. SMNDC1 is a nuclear protein that has been identified as a constituent of the spliceosome complex. This gene is differentially expressed, with abundant levels in skeletal muscle, and may share similar cellular function as the SMN1 gene. This gene is a paralog of SMN1 gene, which encodes the survival motor neuron protein, mutations in which are cause of autosomal recessive proximal spinal muscular atrophy. The protein encoded by this gene is a nuclear protein that has been identified as a constituent of the spliceosome complex. This gene is differentially expressed, with abundant levels in skeletal muscle, and may share similar cellular function as the SMN1 gene.

Partner Proteins

UBC; PRPF3; SF3B5; SND1; CUL3; SF3A2; ELAVL1; HIST3H3; mad2; KPNB1; SNRNP200; SNRPB; CDK5RAP3; PPAN; TSR1; RNMTL1; SF3B1; SF3B3; SF3B2; SF3A3; SF3B4; DDX21; RUVBL1; RPL3; FDFT1; EWSR1

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Sample Type

SMNDC1 is supported by BioGPS gene expression data to be expressed in 721_B

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Goat: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

27kDa

References & Citations

Little, J.T. (2008) J. Biol. Chem. 283 (13), 8145-8152

Shipping Conditions

Wet Ice

Protein Length

238

NCBI Gene Symbol

SMNDC1

NCBI GB Accession Number

SMNDC1

Host or Source

Rabbit

Protein Name

Survival of motor neuron-related-splicing factor 30

Nucleotide Accession Number

NM_005871

Peptide Sequence

KGQVKRSIFASPESVTGKVGVGTCGIADKPMTQYQDTSKYNVRHLMPQ

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