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KARS Antibody - C-terminal region : HRP (ARP40589_P050-HRP)

Product Specifications

Gene Name

Lysyl-tRNA synthetase

Gene Aliases

KRS, KARS, KARS2, LEPID, CMTRIB, DEAPLE, DFNB89

Gene ID

3735

Swiss Prot

Q15046

Accession Number

NP_005539

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Guinea Pig, Horse, Pig, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human KARS

Target

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis.

Partner Proteins

AIMP2; SUMO2; SUMO3; MDM2; UBC; SUMO1; NEDD8; STAT1; SSB; RPL21; RPL19; RPL17; NAP1L4; HSPA4; GPX1; CARS; APEH; CAND1; RANBP6; RPL36; JMJD6; NUDC; IPO7; AIMP1; SH3RF2; FBXO6; vpr; MSK1; gag; FN1; TRMT1; MRPS18B; UBE2S; CCT8; EEF1E1; VBP1; UBA1; RARS; QARS

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

WB, IHC

Purification

Affinity Purified

Sample Type

KARS is strongly supported by BioGPS gene expression data to be expressed in HepG2

Concentration

0.5 mg/ml

Homology

Cow: 92%; Guinea Pig: 85%; Horse: 88%; Human: 100%; Mouse: 79%; Pig: 86%; Rabbit: 86%; Rat: 86%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

66kDa

References & Citations

Halwani, R., (2004) J. Virol. 78 (14), 7553-7564

Shipping Conditions

Wet Ice

Protein Length

597

NCBI Gene Symbol

KARS

NCBI GB Accession Number

KARS

Host or Source

Rabbit

Protein Name

Lysine--tRNA ligase

Nucleotide Accession Number

NM_005548

Peptide Sequence

GMGIDRVAMFLTDSNNIKEVLLFPAMKPEDKKENVATTDTLESTTVGTSV

Frequently Asked Questions

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