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SFPQ Antibody - middle region : Biotin (ARP40571_T100-Biotin)

Selected Variant

ARP40571_T100-Biotin

Size: 100 µL

Product Specifications

Gene Name

Splicing factor proline/glutamine-rich

Gene Aliases

PSF, POMP100, PPP1R140

Gene ID

6421

Swiss Prot

P23246

Accession Number

NP_005057

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human SFPQ

Target

SFPQ is DNA- and RNA binding protein. It is essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as an heteromer with NONO. It binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. It interacts with U5 snRNA. It may be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A. SFPQ may be involved in homologous DNA pairing. SFPQ is involved in transcriptional regulation. It binds the DNA sequence 5'-CTGAGTC-3' in the insulin-like growth factor response element (IGFRE) and inhibits IGF-I-stimulated transcriptional activity.

Partner Proteins

SNRPA; PTBP1; NONO; HDAC2; FUS; HUWE1; UBC; SUMO2; MDM2; STAU1; RPA3; RPA2; RPA1; ERG; ASB18; ASB12; WWOX; ASB3; EED; rev; TIMM23B; APBB1; PIN1; WBP4; TCERG1; GAS7; PRPF40A; PARK2; UBD; CD81; PAN2; RNF43; WHSC1; VCAM1; SMAD5; ITGA4; FN1; CSNK2A1; BTK; DNA

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

IHC, WB

Sample Type

SFPQ is strongly supported by BioGPS gene expression data to be expressed in Jurkat

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 92%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

78kDa

References & Citations

Rosonina, E., (2005) Mol. Cell. Biol. 25 (15), 6734-6746

Shipping Conditions

Wet Ice

Protein Length

707

NCBI Gene Symbol

SFPQ

NCBI GB Accession Number

SFPQ

Host or Source

Rabbit

Protein Name

Splicing factor, proline- and glutamine-rich

Nucleotide Accession Number

NM_005066

Peptide Sequence

PVIVEPLEQLDDEDGLPEKLAQKNPMYQKERETPPRFAQHGTFEYEYSQR

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