IREB2 Antibody - middle region : Biotin (ARP40509_P050-Biotin)

Product Specifications

Gene Name

Iron-responsive element binding protein 2

Gene Aliases

ACO3, IRP2, IRP2AD, NDCAMA, IRE-BP2, IRE-BP 2

Gene ID

3658

Swiss Prot

P48200

Accession Number

NP_004127

Host

Rabbit

Reactivity

Human, Mouse, Rat, Dog, Guinea Pig, Horse, Pig, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human IREB2

Target

IREB2 binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. IREB2 binds to the IRE element in ferritin which results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.

Partner Proteins

RBCK1; UBC; FAM96A; FAM96B; CIAO1; FBXL5; UBA2; TNPO1; CBS; TERT; USP53; APP; PSMA3; VHL; YBX1

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 93%; Pig: 100%; Rabbit: 93%; Rat: 100%; Zebrafish: 93%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.