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PPP1R8 Antibody - middle region : FITC (ARP40412_T100-FITC)

Selected Variant

ARP40412_T100-FITC

Size: 100 µL

Product Specifications

Gene Name

Protein phosphatase 1, regulatory subunit 8

Gene Aliases

ARD1, ARD-1, NIPP1, NIPP-1, PRO2047

Gene ID

5511

Swiss Prot

Q12972

Accession Number

NP_002704

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human PPP1R8

Target

This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA.

Partner Proteins

APPBP2; UBC; FBXO25; HMGA1; WDR77; CTNNBL1; PPIL1; PPP1CC; PPP1CA; NF2; APP; SF3A2; Cep72; PPP1CB; SUZ12; RBBP4; EZH2; EED; RBM48; SF3B1; SETDB1; MELK; HDAC2; C14orf1; STC2; CDC5L; CRMP1; PRKACA; GBP2; LYN; CSNK2A2; CSNK2A1; NME2

Clonality

Polyclonal

Conjugation

FITC: Fluorescein Isothiocyanate

Type

Polyclonal Antibody

Applications

IHC, WB

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 91%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

14kDa

References & Citations

Lesage, B., (2004) J. Biol. Chem. 279 (53), 55978-55984

Shipping Conditions

Wet Ice

Specificity

This antibody recognizes isoform-gamma

Protein Length

127

NCBI Gene Symbol

PPP1R8

NCBI GB Accession Number

PPP1R8

Host or Source

Rabbit

Protein Name

Nuclear inhibitor of protein phosphatase 1

Nucleotide Accession Number

NM_002713

Peptide Sequence

PNLAPDVDLTPVVPSAVNMNPAPNPAVYNPEAVNEPKKKKYAKEAWPGKK

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