EIF4G2 Antibody - C-terminal region : HRP (ARP40361_P050-HRP)

Product Specifications

Gene Name

Eukaryotic translation initiation factor 4 gamma, 2

Gene Aliases

P97, AAG1, DAP5, NAT1

Gene ID

1982

Swiss Prot

P78344

Accession Number

AAH14930

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human EIF4G2

Target

Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. EIF4G2 shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, EIF4G2 functions as a general repressor of translation by forming translationally inactive complexes.

Partner Proteins

SUMO2; UBC; SKIL; RPA2; ITGA4; FN1; Dlg4; POLDIP3; SLIRP; EIF4G3; RAB7A; EIF4H; EIF4G1; EIF4B; EIF4A1; DCUN1D1; EIF3F; MKNK1; EIF2S2; EIF3A; EIF5; EIF4A2; CASP3; NCBP1; EIF4E; MAGEA6

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

WB, IHC

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 93%; Pig: 100%; Rabbit: 100%; Rat: 93%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.