EIF4G2 Antibody - C-terminal region: Biotin (ARP40361_P050-Biotin)
Product Specifications
Gene Name
Eukaryotic translation initiation factor 4 gamma, 2
Gene Aliases
P97, AAG1, DAP5, NAT1
Gene ID
1982
Swiss Prot
P78344
Accession Number
AAH14930
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit
Immunogen
The immunogen is a synthetic peptide directed towards the C terminal region of human EIF4G2
Target
Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. EIF4G2 shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, EIF4G2 functions as a general repressor of translation by forming translationally inactive complexes.
Partner Proteins
SUMO2; UBC; SKIL; RPA2; ITGA4; FN1; Dlg4; POLDIP3; SLIRP; EIF4G3; RAB7A; EIF4H; EIF4G1; EIF4B; EIF4A1; DCUN1D1; EIF3F; MKNK1; EIF2S2; EIF3A; EIF5; EIF4A2; CASP3; NCBP1; EIF4E; MAGEA6
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
WB, IHC
Purification
Affinity Purified
Concentration
0.5 mg/mL
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 93%; Pig: 100%; Rabbit: 100%; Rat: 93%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
39kDa
Shipping Conditions
Wet Ice
Protein Length
352
NCBI Gene Symbol
EIF4G2
Protein Name
Eukaryotic translation initiation factor 4 gamma 2
Nucleotide Accession Number
NM_001042559
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