(D-Trp12, Tyr34) -pTH (7-34) amide (bovine)

(D-Trp12, Tyr34) -pTH (7-34) amide (bovine) is a potent and competitive antagonist of parathyroid hormone (PTH), with a Ki of 69 nM in bovine renal cortical membrane. (D-Trp12, Tyr34) -pTH (7-34) amide (bovine) can be used for growth and development regulation[1][2].

Product Specifications

CAS Number

[118102-98-0]

UNSPSC

12352209

Target

Thyroid Hormone Receptor

Type

Peptides

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/d-trp12-tyr34-pth-7-34-amide-bovine.html

Purity

99.70

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

OC(C=C1)=CC=C1C[C@@H](C(N)=O)NC([C@H](CC(N)=O)NC([C@H](CC2=CNC=N2)NC([C@H](C(C)C)NC([C@H](CC(O)=O)NC([C@H](CCC(N)=O)NC([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H](CC3=CNC4=CC=CC=C34)NC([C@H](CCC(O)=O)NC([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(O)=O)NC([C@H](CCSC)NC([C@H](CO)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@H](CC5=CNC=N5)NC([C@H](CCCCN)NC([C@@H](CC6=CNC7=CC=CC=C67)NC([C@H](CC(C)C)NC([C@H](CC(N)=O)NC([C@H](CC8=CNC=N8)NC([C@H](CCSC)NC([C@H](CC9=CC=CC=C9)N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C165H251N49O40S2

Molecular Weight

3625.25

References & Citations

[1]Goldma ME, et, al. A new highly potent parathyroid hormone antagonist: [D-Trp12, Tyr34]bPTH- (7-34) NH2. Endocrinology. 1988 Nov; 123 (5) : 2597-9.|[2]Pizurki L, et, al. Inhibition by (D-Trp12, Tyr34) bPTH (7-34) amide of PTH and PTHrP effects on Pi transport in renal cells. Am J Physiol. 1990 Aug; 259 (2 Pt 2) : F389-92.|[3]Kukreja SC, Inactivation by plasma may be responsible for lack of efficacy of parathyroid hormone antagonists in hypercalcemia of malignancy. Endocrinology. 1994 May; 134 (5) : 2184-8.