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ANP32A Antibody - middle region : HRP (ARP40203_P050-HRP)

Product Specifications

Gene Name

Acidic (leucine-rich) nuclear phosphoprotein 32 family, member A

Gene Aliases

LANP, MAPM, PP32, HPPCn, PHAP1, PHAPI, I1PP2A, C15orf1

Gene ID

8125

Swiss Prot

P39687

Accession Number

NP_006296

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human ANP32A

Target

ANP32A is a novel potent heat-stable inhibitor protein of protein phosphatase 2A. It may play a key role in self-renewing cell populations where it may act in the nucleus to limit their sensitivity to transformation. Being a tumor suppressor, ANP32A represses cell growth through inhibition of transcription by blocking acetylation and phosphorylation of histone H3 and initiating its proapoptotic activity.

Partner Proteins

UBC; rev; PDLIM5; PLIN3; ARPC1B; OXSR1; EIF4A3; VBP1; TPD52L2; SSB; SRP14; RPA2; PKM; BAG1; SOX2; PCBP1; ESR1; THRB; PPARG; PGR; KPNA6; KPNA5; KPNA1; SUMO2; CHAF1A; HIST1H4A; HIST1H3A; HIST2H2BE; HIST2H2AC; SET; MEPCE; ELAVL1; ADAP1; NSFL1C; HSPB3; AXIN1

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

IHC, WB

Purification

Affinity Purified

Sample Type

ANP32A is supported by BioGPS gene expression data to be expressed in Jurkat

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 100%; Sheep: 86%; Zebrafish: 86%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

29kDa

References & Citations

Stelzl, U., (2005) Cell 122 (6), 957-968

Shipping Conditions

Wet Ice

Protein Length

249

NCBI Gene Symbol

ANP32A

NCBI GB Accession Number

ANP32A

Host or Source

Rabbit

Protein Name

Acidic leucine-rich nuclear phosphoprotein 32 family member A

Nucleotide Accession Number

NM_006305

Peptide Sequence

FNCEVTNLNDYRENVFKLLPQLTYLDGYDRDDKEAPDSDAEGYVEGLDDE

Frequently Asked Questions

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