PRMT2 Antibody - N-terminal region : HRP (ARP40195_P050-HRP)
Selected Variant
ARP40195_P050-HRP
Size: 100 µL
Product Specifications
Gene Name
Protein arginine methyltransferase 2
Gene Aliases
HRMT1L1
Gene ID
3275
Swiss Prot
P55345
Accession Number
NP_001526
Host
Rabbit
Reactivity
Human, Rat
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human PRMT2
Target
The protein arginine methyltransferases (PRMTs) include a family of proteins with related putative methyltransferase domains that modify chromatin and regulate cellular transcription. PRMT2 inhibits NF-kappaB-dependent transcription and promotes apoptosis and it exerts this effect by blocking nuclear export of IkappaB-alpha through a leptomycin-sensitive pathway, increasing nuclear IkappaB-alpha and decreasing NF-kappaB DNA binding. PRMT2 also rendered cells susceptible to apoptosis by cytokines or cytotoxic drugs, likely due to its effects on NF-kappaB.
Partner Proteins
FIP1L1; SPAG8; RIPK2; BAG6; RB1; HNRNPA1; E2F1; UBC; PSMB3; HHV8GK18_gp81; CPSF7; DMRTB1; HNRNPUL1; PRMT2; THRB; PGR; NCOA6; NCOA1; ESR2; RXRA; PRRC2A; ESR1; PPARG; RARA
Clonality
Polyclonal
Conjugation
HRP: Horseradish Peroxidase
Type
Polyclonal Antibody
Applications
WB, CHIP
Purification
Affinity Purified
Sample Type
PRMT2 is strongly supported by BioGPS gene expression data to be expressed in HEK293T
Concentration
0.5 mg/ml
Homology
Human: 100%; Rat: 79%
Format
Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
49kDa
References & Citations
Meyer, R., J. Steroid Biochem. Mol. Biol. 107 (1-2), 1-14 (2007)
Shipping Conditions
Wet Ice
Protein Length
433
NCBI Gene Symbol
PRMT2
NCBI GB Accession Number
PRMT2
Host or Source
Rabbit
Protein Name
Protein arginine N-methyltransferase 2
Nucleotide Accession Number
NM_001535
Peptide Sequence
ERAGCCGYIPANHVGKHVDEYDPEDTWQDEEYFGSYGTLKLHLEMLADQP
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