PRMT2 Antibody - N-terminal region : Biotin (ARP40195_P050-Biotin)
Selected Variant
ARP40195_P050-Biotin
Size: 100 µL
Product Specifications
Gene Name
Protein arginine methyltransferase 2
Gene Aliases
HRMT1L1
Gene ID
3275
Swiss Prot
P55345
Accession Number
NP_001526
Host
Rabbit
Reactivity
Human, Rat
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human PRMT2
Target
The protein arginine methyltransferases (PRMTs) include a family of proteins with related putative methyltransferase domains that modify chromatin and regulate cellular transcription. PRMT2 inhibits NF-kappaB-dependent transcription and promotes apoptosis and it exerts this effect by blocking nuclear export of IkappaB-alpha through a leptomycin-sensitive pathway, increasing nuclear IkappaB-alpha and decreasing NF-kappaB DNA binding. PRMT2 also rendered cells susceptible to apoptosis by cytokines or cytotoxic drugs, likely due to its effects on NF-kappaB.
Partner Proteins
FIP1L1; SPAG8; RIPK2; BAG6; RB1; HNRNPA1; E2F1; UBC; PSMB3; HHV8GK18_gp81; CPSF7; DMRTB1; HNRNPUL1; PRMT2; THRB; PGR; NCOA6; NCOA1; ESR2; RXRA; PRRC2A; ESR1; PPARG; RARA
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
WB, CHIP
Purification
Affinity Purified
Sample Type
PRMT2 is strongly supported by BioGPS gene expression data to be expressed in HEK293T
Concentration
0.5 mg/ml
Homology
Human: 100%; Rat: 79%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
49kDa
References & Citations
Meyer, R., J. Steroid Biochem. Mol. Biol. 107 (1-2), 1-14 (2007)
Shipping Conditions
Wet Ice
Protein Length
433
NCBI Gene Symbol
PRMT2
NCBI GB Accession Number
PRMT2
Host or Source
Rabbit
Protein Name
Protein arginine N-methyltransferase 2
Nucleotide Accession Number
NM_001535
Peptide Sequence
ERAGCCGYIPANHVGKHVDEYDPEDTWQDEEYFGSYGTLKLHLEMLADQP
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