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PRMT5 Antibody - N-terminal region : FITC (ARP40185_T100-FITC)

Product Specifications

Gene Name

Protein arginine methyltransferase 5

Gene Aliases

HSL7, JBP1, SKB1, IBP72, SKB1Hs, HRMT1L5

Gene ID

10419

Swiss Prot

O14744

Accession Number

NP_001034708

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human PRMT5

Target

PRMT5 methylates specific arginine residues in the small nuclear ribonucleoproteins Sm D1 and Sm D3 to monomethylarginine and to symmetrical dimethylarginines (sDMAs) . It methylates SUPT5H. PRMT5 plays a role in the assembly of snRNP core particles and may play a role in cytokine-activated transduction pathways. It negatively regulates cyclin E1 promoter activity and cellular proliferation and May regulate the SUPT5H transcriptional elongation properties. It may be part of a pathway that is connected to a chloride current, possibly through cytoskeletal rearrangement. PRMT5 methylates histone H2A/H4 'Arg-3' during germ cell development and methylates histone H3 'Arg-8', which may repress transcription.

Partner Proteins

UBC; TP53; ING2; PRDM1; NFE4; WDR5; SUMO2; WWOX; CDYL2; LENG8; LDHAL6B; PRPF38A; ING5; ZNF436; WDR77; GRHL3; TRIB3; RSRP1; LUC7L; RBM23; GTPBP2; H3F3C; FOXK1; ZUFSP; FAM76B; NUDCD2; MAGEB2; NELFCD; COPS4; COPS7A; DCAF8; SPAG8; SLU7; MCRS1; CUL4A; ZNF2; YW

Clonality

Polyclonal

Conjugation

FITC: Fluorescein Isothiocyanate

Type

Polyclonal Antibody

Applications

IHC, WB

Sample Type

PRMT5 is supported by BioGPS gene expression data to be expressed in Jurkat

Concentration

0.5 mg/ml

Homology

Cow: 93%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 77%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

68kDa

References & Citations

Azzouz, T.N., (2005) J. Biol. Chem. 280 (41), 34435-34440

Shipping Conditions

Wet Ice

Protein Length

620

NCBI Gene Symbol

PRMT5

NCBI GB Accession Number

PRMT5

Host or Source

Rabbit

Protein Name

Protein arginine N-methyltransferase 5

Nucleotide Accession Number

NM_001039619

Peptide Sequence

FDFLCMPVFHPRFKREFIQEPAKNRPGPQTRSDLLLSGRDWNTLIVGKLS

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