INSIG1 Antibody - middle region : Biotin (ARP40166_P050-Biotin)

Product Specifications

Gene Name

Insulin induced gene 2

Gene Aliases

INSIG-2

Gene ID

51141

Swiss Prot

Q9Y5U4

Accession Number

NP_057217

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Pig, Rabbit, Sheep, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human INSIG1

Target

Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR) - and sterol regulatory element-binding protein (SREBP) -mediated signaling pathways. This gene is an insulin-induced gene. INSIG1 is an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. INSIG1 binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins.The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Partner Proteins

RNF5; HMGCR; SCAP; SREBF1; RNF139; UBQLN1; UBQLN2; FAF2; ADRM1; PSMD14; BAG6; VCP; UBC; RPN1; PSMD13; PSMD12; PSMD11; PSMD4; PSMC6; PSMC5; PSMC3; PSMC2; PSMB3; PSMB1; PSMA7; PSMA2; LGALS7; JUP; INSIG1; HSPA8; HSPA6; HSPA5; HSPA1A; ENO1; DSP; AMFR; SREBF2

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

Purification

Affinity Purified

Sample Type

INSIG2 is supported by BioGPS gene expression data to be expressed in 721_B

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Goat: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%; Zebrafish: 87%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.