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JMJD3 Antibody - N-terminal region : HRP (ARP40101_P050-HRP)

Selected Variant

ARP40101_P050-HRP

Size: 100 µL

Product Specifications

Gene Name

Lysine (K) -specific demethylase 6B

Gene Aliases

JMJD3, NEDCFSA

Gene ID

23135

Swiss Prot

O15054

Accession Number

NP_001073893

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human JMJD3

Target

JMJD3 is a histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. It plays a central role in regulation of posterior development, by regulating HOX gene expression. It is involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation.

Partner Proteins

WDR5; ASH2L; RBBP5; UBC; TK1; CSNK2B; HIST1H3A; WAS; SMAD3; SMAD2; SMAD4; SMAD1

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 93%; Rabbit: 100%; Rat: 100%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

181kDa

References & Citations

Hong, S., (2007) Proc. Natl. Acad. Sci. U.S.A. 104 (47), 18439-18444

Shipping Conditions

Wet Ice

Protein Length

1682

NCBI Gene Symbol

KDM6B

NCBI GB Accession Number

KDM6B

Host or Source

Rabbit

Protein Name

Lysine-specific demethylase 6B

Nucleotide Accession Number

NM_001080424

Peptide Sequence

HRAVDPPGARAAREAFALGGLSCAGAWSSCPPHPPPRSAWLPGGRCSASI

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