RNF8 Antibody - C-terminal region: HRP (ARP40071_T100-HRP)
Product Specifications
Gene Name
Ring finger protein 8, E3 ubiquitin protein ligase
Gene Aliases
HRNF8
Gene ID
9025
Swiss Prot
O76064
Accession Number
NP_003949
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit
Immunogen
The immunogen is a synthetic peptide directed towards the C terminal region of human RNF8
Target
RNF8 contains a RING finger motif and a FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins.The protein encoded by this gene contains a RING finger motif and a FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Partner Proteins
TMEM79; HOMEZ; SEPT3; RBFOX2; PNMA2; USP16; WASL; HERC2; MAD1L1; VCP; TNFRSF1A; TNF; BCL10; UBE2N; UBC; NEDD8; JMJD1C; MDC1; EXOSC2; MDM2; BLM; SEPT8; SEPT7; RPSA; H2AFX; RL2; HIST2H2BE; HIST2H2AC; PCNA; RAD50; NBN; MRE11A; UBE2E3; UBE2V1; UBE2E2; UBE2E1
Clonality
Polyclonal
Conjugation
HRP: Horseradish Peroxidase
Type
Polyclonal Antibody
Applications
IHC, WB
Concentration
0.5 mg/mL
Homology
Cow: 100%; Dog: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 92%; Rat: 100%
Format
Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
55kDa
Shipping Conditions
Wet Ice
Protein Length
485
NCBI Gene Symbol
RNF8
Protein Name
E3 ubiquitin-protein ligase RNF8
Nucleotide Accession Number
NM_003958
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