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UTX Antibody - C-terminal region : FITC (ARP39483_P050-FITC)

Product Specifications

Gene Name

Lysine (K) -specific demethylase 6A

Gene Aliases

UTX, KABUK2, bA386N14.2

Gene ID

7403

Swiss Prot

O15550

Accession Number

NP_066963

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human UTX

Target

UTX is a histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. It demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. UTX plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitent with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A.

Partner Proteins

KMT2D; WDR5; ASH2L; RBBP5; SMAD9; HIST2H3C; SRF; SMARCA4; GATA4; NKX2-5; TBX5; UBC; HIST1H3A; WDR82; PAXIP1; NCOA6; TLE1; PROSER1; KMT2C; N4BP2; PPP6R3; ZNF281; HIST3H3

Clonality

Polyclonal

Conjugation

FITC: Fluorescein Isothiocyanate

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Sample Type

KDM6A is strongly supported by BioGPS gene expression data to be expressed in MCF7

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 86%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

154kDa

References & Citations

Hong, S., (2007) Proc. Natl. Acad. Sci. U.S.A. 104 (47), 18439-18444

Shipping Conditions

Wet Ice

Protein Length

1401

NCBI Gene Symbol

KDM6A

NCBI GB Accession Number

KDM6A

Host or Source

Rabbit

Protein Name

Lysine-specific demethylase 6A

Nucleotide Accession Number

NM_021140

Peptide Sequence

KTYIVHCQDCARKTSGNLENFVVLEQYKMEDLMQVYDQFTLAPPLPSASS

Frequently Asked Questions

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