DEAF1 Antibody - C-terminal region : Biotin (ARP39468_P050-Biotin)

Product Specifications

Gene Name

Deformed epidermal autoregulatory factor 1 (Drosophila)

Gene Aliases

SPN, NUDR, VSVS, MRD24, ZMYND5, NEDHELS

Gene ID

10522

Swiss Prot

O75398

Accession Number

NP_066288

Host

Rabbit

Reactivity

Human, Mouse, Rat, Dog, Guinea Pig, Horse, Pig

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human DEAF1

Target

DEAF1 down-regulates transcription of those genes by binding to sequence with multiple copies of TTC[CG]G present in their own promoter and that of the HNRPA2B1 gene. DEAF1 binds to the retinoic acid response element (RARE) AGGGTTCACCGAAAGTTCA. DEAF1 activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase.

Partner Proteins

IRF7; IRF3; CREB1; PELI1; PELI2; HRSP12; GSK3B; GSK3A; CDKN2A; PPP1CC; PPP1CA; CDC37; AIMP2; TK1; RAD23B; PIN1; HRAS; FHL1; CDKN1A; ASCC2; INTS1; LMO4; DEAF1

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

Purification

Affinity Purified

Sample Type

DEAF1 is supported by BioGPS gene expression data to be expressed in Jurkat

Concentration

0.5 mg/ml

Homology

Dog: 86%; Guinea Pig: 79%; Horse: 86%; Human: 100%; Mouse: 79%; Pig: 93%; Rat: 79%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.